1. Finding Product-Market Fit: Twitter’s Evolution Through 7 Markets by Brendan Baker. “Product-market fit is not obvious at first, and can emerge, evolve and extinguish. There can also be more than one product-market fit. Twitter is a prime example of a core concept shifting through different markets over time.”
  2. Make Product Decisions Without Doubt — My Lessons from Twitter and Slack by Tess Rosania at First Round. Big product decisions are often hard and seldom without controversy. Rosania on some of the big decisions they made and how they played out.
  3. How to Take Bigger, Bolder Product Bets — Lessons from Slack’s Chief Product Officer with Noah Desai Weiss at First Round. “A hard problem, he says, can’t be solved by experimenting your way out of it. “You have to figure out if it’s a big swing you want to take. You do that by using intuition.””
  4. Total And Different Dietary Fiber Subtypes And The Risk Of All-cause, Cardiovascular, And Cancer Mortality: A Dose-response Meta-analysis Of Prospective Cohort Studies by Mirrafiei et al. (2023). This meta-analysis (n > 1 mio) found that consuming up to 40 grams of fiber per day was linked to a 45% reduction in risk of all-cause mortality.
  5. Design Of Highly Functional Genome Editors By Modeling The Universe Of CRISPR-Cas Sequences by Ruffolo et al. (2024). AI models were trained to generate a wide variety of gene editors, including some that are even better than the commonly used SpCas9 editor.
  6. A Morning With The Rabbit R1: A Fun, Funky, Unfinished AI Gadget by David Pierce at The Verge. While the rabbit doesn’t pass the review with flying colours, it is fun to envision all the new types of hardware designs beyond the standard phone.
  7. What Can LLMs Never Do? at Strange Loop Canon. While many focus on LLMs’ capabilities, exploring their limitations through tasks seemingly simple for humans can reveal a lot about their true potential.